Article
Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype.
The European respiratory journal - 1 Apr 2021
Declercq Mathias, de Zeeuw Pauline, Conchinha Nadine V, Geldhof Vincent, Ramalho Anabela S, García-Caballero Melissa, Brepoels Katleen, Ensinck Marjolein, Carlon Marianne S, Bird Matthew J, Vinckier Stefan, Proesmans Marijke, Vermeulen François, Dupont Lieven, Ghesquière Bart, Dewerchin Mieke, Carmeliet Peter, Cassiman David, Treps Lucas, Eelen Guy, Witters Peter
Abstract excerpt
Cystic fibrosis (CF) is a life-threatening disorder characterised by decreased pulmonary mucociliary and pathogen clearance, and an exaggerated inflammatory response leading to progressive lung damage. CF is caused by bi-allelic pathogenic variants of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a chloride channel. CFTR is expressed in endothelial cells (ECs) and EC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.