Article

Metabolic task analysis reveals distinct metabotypes in end-stage dilated cardiomyopathy

2025-04-02

Abstract excerpt

Dilated cardiomyopathy (DCM) is associated with shifts in cardiac metabolism. Those shifts are inconsistent between patients, possibly due to heterogeneity in DCM etiologies. Identifying metabolic subtypes, or metabotypes, in DCM patients may open personalized treatment opportunities. Developing a methodology to identify metabotypes would be a boon in this regard. Here, we describe a metabotyping pipeline, integra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1da4b09-2a6c-5675-86a0-6da82c99fa97
DOI: 10.1101/2025.03.28.645901

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic task analysis reveals distinct metabotypes in end-stage dilated cardiomyopathyDOI 10.1101/2025.03.28.645901Read

Clustering of Cardiac Transcriptome Profiles Reveals UniqueSemantic proximity Read

Identifying functional metabolic shifts in heart failure with the integration of omics data and a cardiomyocyte-specific, genome-scale modelSemantic proximity Read

Proteogenomics of Hypertrophic Cardiomyopathy Reveals Subtype-Specific Therapy.Semantic proximity Read

Transcriptome Data Analysis of Primary Cardiomyopathies Reveals Perturbations in Arachidonic Acid MetabolismSemantic proximity Read

Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences.Semantic proximity Read

Cell-type-resolved Metabolic Flux Inference Reveals Stromal Metabolic Reprogramming Across Human CardiomyopathiesSemantic proximity Read

Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy.Semantic proximity Read

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathySemantic proximity Read

An 'Omics' Perspective on Cardiomyopathies and Heart Failure.Semantic proximity Read

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.Semantic proximity Read

Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling.Semantic proximity Read

Multi-omics reveals lipid metabolism, mitochondrial and extracellular matrix dysregulation of diabetic cardiomyopathy in the human heartSemantic proximity Read