Article

Multi-omics reveals lipid metabolism, mitochondrial and extracellular matrix dysregulation of diabetic cardiomyopathy in the human heart

2025-08-22

Abstract excerpt

Diabetic cardiomyopathy (DbCM) is a condition characterized by myocardial dysfunction in diabetes. Although the clinical recognition of DbCM is increasing, its underlying molecular mechanisms remain poorly understood. We aimed to conduct a comprehensive multi-omics analysis of heart tissue from cardiomyopathy patients (both with and without diabetes), alongside tissue from healthy donors, by integrating transcript...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d344e14d-b76c-503a-9592-c0ac39b47177
DOI: 10.1101/2025.08.21.671651

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omics reveals lipid metabolism, mitochondrial and extracellular matrix dysregulation of diabetic cardiomyopathy in the human heartDOI 10.1101/2025.08.21.671651Read

Multi-omics insights into the pathogenesis of diabetic cardiomyopathy: epigenetic and metabolic profilesSemantic proximity Read

Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathySemantic proximity Read

Linking Fatty Acid Metabolism to Diabetic Cardiomyopathy: The Role of Mitochondrial Dysfunction and Immune Microenvironment Alterations, a Bioinformatics ApproachSemantic proximity Read

Transcriptome Data Analysis of Primary Cardiomyopathies Reveals Perturbations in Arachidonic Acid MetabolismSemantic proximity Read

Role of mitochondrial metabolic disorder and immune infiltration in diabetic cardiomyopathy: new insights from bioinformatics analysisSemantic proximity Read

The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modificationsSemantic proximity Read

Integrative Analysis of Left Ventricle and Epicardial Adipose Tissue Identifies SDHA and OGDH as Candidate Targets for Ischemic Heart DiseaseSemantic proximity Read

Mitophagy in Diabetic Cardiomyopathy: Roles and MechanismsSemantic proximity Read

Integrative proteomic and metabolomic elucidation of cardiomyopathy with in vivo and in vitro models and clinical samplesSemantic proximity Read

Role of mitochondrial metabolic disorder and immune infiltration in diabetic cardiomyopathy: new insights from bioinformatics analysisSemantic proximity Read

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological StrategiesSemantic proximity Read

The Role of Mitochondrial Abnormalities in Diabetic CardiomyopathySemantic proximity Read