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Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers

5 May 2020

Abstract excerpt

Most cancers have lost a critical DNA damage response (DDR) pathway during tumor evolution. These alterations provide a useful explanation for the initial sensitivity of tumors to DNA-targeting chemotherapy. A striking example is dysfunctional homology-directed repair (HDR), e.g. due to inactivating mutations in BRCA1 and BRCA2 genes. Extensive efforts are being made to develop novel targeted therapies exploiting...

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PMID: 32432041
DOI: 10.3389/fonc.2020.00670

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