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Evolutionary formation of a human <i>de novo</i> open reading frame from a non-primate non-coding genomic region that proceeds via biased random mutations

2023-08-12

Abstract excerpt

Two open reading frames (ORFs) of evolutionary interest stem from the human gene SMIM45 . An investigation shows that one consists of an ultra-conserved 68 amino acid (aa) sequence that dates back to the amphibians, ∼192 MYA. In contrast, the other, an ORF of 107 aa develops slowly during primate evolution. An early developmental stage of the 107 aa ORF has been detected in non-primate genomes. In the mouse, it c...

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Identifiers and source

Literature Corpus work
f1a34a31-820f-5896-a500-547c7f1fb135
DOI
10.1101/2023.08.09.552707
Open publication

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Evolutionary formation of a human <i>de novo</i> open reading frame from a non-primate non-coding genomic region that proceeds via biased random mutationsDOI 10.1101/2023.08.09.552707
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