Article

Evolutionary formation of a human de novo open reading frame from a mouse non-coding DNA sequence via biased random mutations

2023-08-29

Abstract excerpt

Two open reading frames (ORFs) of evolutionary interest stem from the human gene SMIM45 . An investigation shows that one consists of an ultra-conserved 68 amino acid (aa) sequence that dates back to the amphibians, ~350 MYA. In contrast, the other, an 107 aa ORF develops slowly during primate evolution. An early embryonic stage of development has been detected in the mouse genome that consists of a small sequence...

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Literature Corpus work: 74212406-a4f1-5dba-90e5-a4195203fd24
DOI: 10.21203/rs.3.rs-3209663/v1

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