Article

Generation of <i>de novo</i> miRNAs from template switching during DNA replication

2023-04-20

Abstract excerpt

The mechanisms generating novel genes and genetic information are poorly known, even for microRNA (miRNA) genes with an extremely constrained design. All miRNA primary transcripts need to fold into a stem-loop structure to yield short gene products (∼22 nt) that bind and reppress their mRNA targets. While a substantial number of miRNA genes are ancient and highly conserved, short secondary structures coding for en...

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Literature Corpus work: 6a2e2b1a-a7cc-56aa-bd23-14fc7a6fc6d2
DOI: 10.1101/2023.04.19.537475

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