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Article

Death and Resurrection of the Human IRGM Gene

6 Mar 2009

Abstract excerpt

Immunity-related GTPases (IRG) play an important role in defense against intracellular pathogens. One member of this gene family in humans, IRGM, has been recently implicated as a risk factor for Crohn's disease. We analyzed the detailed structure of this gene family among primates and showed that most of the IRG gene cluster was deleted early in primate evolution, after the divergence of the anthropoids from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19266026
DOI: 10.1371/journal.pgen.1000403

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