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A Generalizable Machine Learning Framework for cfDNA based Early Detection of Hepatocellular Carcinoma: a Feasibility Study with Preclinical Validation

2025-06-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>PURPOSE</h4> Early detection of hepatocellular carcinoma (HCC) is critical for improving patient outcomes, yet current screening tools lack sensitivity and specificity. We demonstrate a flexible machine learning framework for HCC detection using methylation profiles from bisulfite sequencing across multiple assay platforms and sample types. The framework supports a “split-and-filter” approa...

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Literature Corpus work
f189f71f-0947-5362-8aeb-943d95bfa381
DOI
10.1101/2025.06.09.658649
Open publication

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A Generalizable Machine Learning Framework for cfDNA based Early Detection of Hepatocellular Carcinoma: a Feasibility Study with Preclinical ValidationDOI 10.1101/2025.06.09.658649
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