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Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation

31 Aug 2018

Abstract excerpt

Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive surveillance tools are needed. We aimed to identify and validate methylated DNA markers (MDMs) for HCC detection. Reduced representation bisulfite sequencing was performed on DNA extracted from 18 HCC and 35 control tissues. Candidate MDMs were confirmed by quantitative methylation-specific PCR in DNA from independent tissues...

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Cancer Genomics and Diagnostics
Epigenetics and DNA Methylation
Ferroptosis and cancer prognosis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30168613
DOI: 10.1002/hep.30244

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