Article

Chronic Interferon Stimulated Gene Transcription Promotes Oncogene Induced Breast Cancer

2023-10-16

Abstract excerpt

The Mre11 complex (comprising Mre11, Rad50, Nbs1) is integral to the maintenance of genome stability. We previously showed that a hypomorphic Mre11 mutant mouse strain ( Mre11 ATLD1/ATLD1 ) was highly susceptible to oncogene induced breast cancer. Here we used a mammary organoid system to examine which Mre11 dependent responses are tumor suppressive. We found that Mre11 ATLD1/ATLD1 organoids exhibited an elev...

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Literature Corpus work: 2d00773c-095d-5774-b5eb-2c7f13418fb3
DOI: 10.1101/2023.10.16.562529

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