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Article

Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1-Mutant Breast Cancer.

Cancer research - 1 Feb 2021

Williams Michelle M, Spoelstra Nicole S, Arnesen Spencer, O'Neill Kathleen I, Christenson Jessica L, Reese Jordan, Torkko Kathleen C, Goodspeed Andrew, Rosas Emmanuel, Hanamura Toru, Sams Sharon B, Li Zheqi, Oesterreich Steffi, Riggins Rebecca B, Jacobsen Britta M, Elias Anthony, Gertz Jason, Richer Jennifer K

Abstract excerpt

Mutations in ESR1 that confer constitutive estrogen receptor alpha (ER) activity in the absence of ligand are acquired by ≥40% of metastatic breast cancers (MBC) resistant to adjuvant aromatase inhibitor (AI) therapy. To identify targetable vulnerabilities in MBC, we examined steroid hormone receptors and tumor-infiltrating immune cells in metastatic lesions with or without ER mutations. ER and progesterone...

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Source

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Identifiers

PMID: 33184106
DOI: 10.1158/0008-5472.CAN-20-1200
PMCID: PMC7854521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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