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RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells

21 Nov 2014

Abstract excerpt

RUNX1 encodes a RUNX family transcription factor (TF) and was recently identified as a novel mutated gene in human luminal breast cancers. We found that Runx1 is expressed in all subpopulations of murine mammary epithelial cells (MECs) except the secretory alveolar luminal cells. Conditional knockout of Runx1 in MECs by MMTV-Cre led to a decrease in luminal MECs, largely due to a profound reduction in the...

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PMID: 25415051
DOI: 10.7554/elife.03881

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