Article

Polyunsaturated Fatty Acids Promote Protumoral Macrophage Polarization via a RhoA-YAP1 Signaling Pathway in the Ovarian Cancer Microenvironment

2022-12-29

Abstract excerpt

<title>Abstract</title> <p>Tumor-associated macrophages (TAMs) are crucially associated with tumor development and progression; however, it remains unclear how the tumor microenvironment (TME) rewires the metabolic circuits and preferentially induces TAMs to polarize toward a protumoral phenotype. Here, we report that polyunsaturated fatty acids (PUFAs) in malignant ascites promote protumoral M2-like TAMs deposit...

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Literature Corpus work: f1652079-75b9-5e04-95bc-9a3c87f3686e
DOI: 10.21203/rs.3.rs-2384228/v1

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