Metabolic molecular subtyping of ovarian cancer reveals the role of oleic acid-CD36 in facilitating cisplatin resistance

Abstract excerpt

<title>Abstract</title> <p>Current histopathological classification systems for ovarian cancer cannot adequately predict platinum chemotherapy response, hindering personalized therapeutic strategies. Here, through integrative analysis of multiple datasets from TCGA, ICGC and GEO databases, we stratify patients into metabolic associated chemotherapy-refractory and chemotherapy-sensitive types (MCRT, MCST for short...

Topics

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• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Cancer, Lipids, and Metabolism
• Cellular transport and secretion
• DNA Repair Mechanisms
• Endoplasmic Reticulum Stress and Disease
• Ferroptosis and cancer prognosis
• Ovarian cancer diagnosis and treatment

Identifiers and source

Literature Corpus work

62994a44-686e-5b92-99fe-e2a17d31b529

DOI

10.21203/rs.3.rs-7929093/v1