Article
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
The Journal of experimental medicine - 4 Nov 2019
Futch Hunter S, McFarland Karen N, Moore Brenda D, Kuhn M Zino, Giasson Benoit I, Ladd Thomas B, Scott Karen A, Shapiro Melanie R, Nosacka Rachel L, Goodwin Marshall S, Ran Yong, Cruz Pedro E, Ryu Daniel H, Croft Cara L, Levites Yona, Janus Christopher, Chakrabarty Paramita, Judge Andrew R, Brusko Todd M, de Kloet Annette D, Krause Eric G, Golde Todd E
Abstract excerpt
Hypothalamic-pituitary-adrenal (HPA) axis dysfunction contributes to numerous human diseases and disorders. We developed a high-affinity monoclonal antibody, CTRND05, targeting corticotropin-releasing factor (CRF). In mice, CTRND05 blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of the HPA axis. CTRND05...
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