Article
Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development.
Neuron - 1 Jun 1998
Smith G W, Aubry J M, Dellu F, Contarino A, Bilezikjian L M, Gold L H, Chen R, Marchuk Y, Hauser C, Bentley C A, Sawchenko P E, Koob G F, Vale W, Lee K F
Abstract excerpt
Corticotropin releasing factor (CRF) is a major integrator of adaptive responses to stress. Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and CRFR2) have been described. We have generated mice null for the CRFR1 gene to elucidate the specific developmental and phys...
Topics
- Adaptation, Physiological
- Adrenal Gland Diseases
- Adrenal Glands
- Adrenocorticotropic Hormone
- Animals
- Anxiety
- Behavior, Animal
- Chimera
- Corticosterone
- Female
- Gene Expression Regulation, Developmental
- Homozygote
- Male
- Maze Learning