Article

ITGA5 promotes homologous recombination mediated radioresistance in esophageal squamous cell carcinoma by upregulating RAD51AP1 expression

2025-12-17

Abstract excerpt

<title>Abstract</title> <p>Radiotherapy resistance represents a critical barrier to successful treatment of esophageal squamous cell carcinoma (ESCC), driving tumor recurrence and poor patient survival. We establish constitutive overexpression of integrin α5 (ITGA5) as a central molecular determinant of ESCC radioresistance. Clinically, elevated ITGA5 expression correlates with radiation therapy failure and reduc...

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Literature Corpus work: f0f7168e-8657-5400-b378-c5753b1cbe97
DOI: 10.21203/rs.3.rs-8195442/v1

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