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Article

Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation.

Molecular cancer therapeutics - 1 Feb 2020

Jiang Wei, Wu Yutuan, He Tiancong, Zhu Hanting, Ke Guihao, Xiang Libing, Yang Huijuan

Abstract excerpt

This study aims to explore whether E545K, the most common hotspot mutation of PIK3CA in cervical cancer, confers radioresistance to cervical cancer cells, to demonstrate the underling mechanism, and to develop the effective targets. SiHa and MS751 cells with PIK3CA-WT and PIK3CA-E545K were established by lentiviral transfection. The radiosensitivity was assessed by colony formation, cell cycle, cell apoptosis,...

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PMID: 31666350
DOI: 10.1158/1535-7163.MCT-19-0309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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