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Article

ATF5 and HIF1α cooperatively activate HIF1 signaling pathway in esophageal cancer

12 May 2021

Abstract excerpt

BACKGROUND: Esophageal cancer (ESCA) is one of the most common cancers worldwide and has a very poor prognosis. Hypoxia-inducible factor 1 (HIF1) signaling pathway plays a critical role in tumorigenesis and is therefore considered a potential therapeutic target in the treatment of many cancers. Activating transcription factor 5 (ATF5) facilitates the expression of various genes and has been extensively studied...

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PMID: 33980247
DOI: 10.1186/s12964-021-00734-x

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