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Article

Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells

1 Mar 2011

Abstract excerpt

High grade gliomas (HGGs) are characterized by resistance to radiotherapy and chemotherapy. Targeting Rad51-dependent homologous recombination repair may be an effective target for chemo- and radiosensitization. In this study we assessed the role of Rad51-dependent repair on sensitivity to radiation and temozolomide (TMZ) as single agents or in combination. Repair protein levels in established glioma cell lines,...

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PMID: 21363882
DOI: 10.1093/neuonc/nor010

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