Article
Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes.
Biochimica et biophysica acta - 1 May 2016
Cai Junyan, Shi Xiaoqin, Wang Huamin, Fan Jinghui, Feng Yongliang, Lin Xianjuan, Yang Jichun, Cui Qinghua, Tang Chaoshu, Xu Guoheng, Geng Bin
Abstract excerpt
Adipocytes express the cystathionine γ lyase (CSE)-hydrogen sulfide (H2S) system. CSE-H2S promotes adipogenesis but ameliorates adipocyte insulin resistance. We investigated the mechanism of how CSE-H2S induces these paradoxical effects. First, we confirmed that an H2S donor or CSE overexpression promoted adipocyte differentiation. Second, we found that H2S donor inhibited but CSE inhibition increased...
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