Article
Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory.
Learning & memory (Cold Spring Harbor, N.Y.) - 16 Jul 2012
Leach Prescott T, Poplawski Shane G, Kenney Justin W, Hoffman Barbara, Liebermann Dan A, Abel Ted, Gould Thomas J
Abstract excerpt
Growth arrest and DNA damage-inducible β (Gadd45b) has been shown to be involved in DNA demethylation and may be important for cognitive processes. Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with cognitive deficits. Furthermore, several high-throughput screens have identified Gadd45b as a candidate plasticity-related gene. However, a direct demonstration of a...
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