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Article

Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48

28 Aug 2013

Abstract excerpt

To distinguish age-related memory loss more explicitly from Alzheimer's disease (AD), we have explored its molecular underpinning in the dentate gyrus (DG), a subregion of the hippocampal formation thought to be targeted by aging. We carried out a gene expression study in human postmortem tissue harvested from both DG and entorhinal cortex (EC), a neighboring subregion unaffected by aging and known to be the site...

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PMID: 23986399
DOI: 10.1126/scitranslmed.3006373

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