Article

Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer’s disease

2022-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Oxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer’s disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating repair of oxidative DNA base lesions and with a distinct expression pattern in proliferating cells. In brain, its function has been linked to hippocampal-dependent memory and...

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Literature Corpus work: e13ed697-f70c-55c9-aab9-cb3d85360d32
DOI: 10.1101/2022.03.10.483733

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