Article

ZBED2 is an antagonist of Interferon Regulatory Factor 1 and modulates cell identity in pancreatic cancer

2019-12-06

Abstract excerpt

<h4>ABSTRACT</h4> Lineage plasticity is a prominent feature of pancreatic ductal adenocarcinoma (PDA) cells, which can occur via deregulation of lineage-specifying transcription factors. Here, we show that the zinc finger protein ZBED2 is aberrantly expressed in PDA and alters tumor cell identity in this disease. Unexpectedly, our epigenomic experiments reveal that ZBED2 is a sequence-specific transcriptional rep...

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Literature Corpus work: f0aa4dcf-0fdc-53be-bb04-9ea0e5969b65
DOI: 10.1101/868141

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