Article
Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.
Nucleic acids research - 20 Jun 2017
Mishra Vivek Kumar, Wegwitz Florian, Kosinsky Robyn Laura, Sen Madhobi, Baumgartner Roland, Wulff Tanja, Siveke Jens T, Schildhaus Hans-Ulrich, Najafova Zeynab, Kari Vijayalakshmi, Kohlhof Hella, Hessmann Elisabeth, Johnsen Steven A
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a particularly dismal prognosis. Histone deacetylases (HDAC) are epigenetic modulators whose activity is frequently deregulated in various cancers including PDAC. In particular, class-I HDACs (HDAC 1, 2, 3 and 8) have been shown to play an important role in PDAC. In this study, we investigated the effects of the class I-specific HDAC...
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