Article

Genetic Analysis of Primary Aldosteronism Bridging Disease Subtypes and the Phenotypic Continuum

2026-08-18

Abstract excerpt

Primary aldosteronism (PA) is a common cause of secondary hypertension. To investigate its genetic basis, we perform a trans-ancestry genome-wide association study (GWAS) meta-analysis, with subtype-specific analyses for aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH). Subsequently, we conduct genetic mediation analysis to partition PA effects on cardiovascular outcomes into blood press...

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Literature Corpus work: f0922c6f-1f39-5c9f-b975-815c5168d815
DOI: 10.64898/2026.08.16.26359407

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