Article

A Familial Alzheimer’s Disease Associated Mutation in Presenilin-1 Mediates Amyloid-Beta Independent Cell Specific Neurodegeneration

2023-07-19

Abstract excerpt

Mutations in the presenilin ( PS ) genes are a predominant cause of familial Alzheimer’s disease (fAD). An ortholog of PS in the genetic model organism Caenorhabditis elegans (C. elegans) is sel-12 . Mutations in the presenilin genes are commonly thought to lead to fAD by upregulating the expression of amyloid beta (Aβ), however this hypothesis has been challenged by recent evidence. As C. elegans lack amyloi...

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Literature Corpus work: f08c0566-c889-536d-b5f9-9bc6c45a4019
DOI: 10.1101/2023.07.19.549777

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