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Article

The presenilin 1 C92S mutation increases abeta 42 production.

Biochemical and biophysical research communications - 14 Oct 2000

Lewis P A, Perez-Tur J, Golde T E, Hardy J

Abstract excerpt

Although wild-type human presenilin 1 (PS1) rescues the C. elegans egg-laying (egl) phenotype that is caused by a loss of function mutation in the C. elegans presenilin homologue sel12, most familial Alzheimer's disease (FAD)-linked PS1 mutants only partially rescue this phenotype. To investigate the effects of the loss of function sel12 mutation on Abeta production in mammalian cells, we analyzed Abeta...

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PMID: 11027672
DOI: 10.1006/bbrc.2000.3646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The presenilin 1 C92S mutation increases abeta 42 production.PMID 11027672Read ↗

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