Article
Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.
Genes and function - 1 Apr 1997
Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grünberg J, Haass C
Abstract excerpt
The majority of cases with familial Alzheimer's disease (FAD) are linked to mutations of the presenilin (PS) genes. These genes show considerable sequence similarity to the sel-12 gene of Caenorhabditis elegans, which has been postulated to function in the facilitated signalling by lin-12 and glp...
Topics
- Alzheimer Disease
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Humans
- Hydrolysis
- Membrane Proteins
- Mutation
- Phenotype
- Plasmids
- Presenilin-1
- Protein Processing, Post-Translational
- Receptors, Notch
- Recombinant Proteins