Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APL-1, a <i>Caenorhabditis elegans</i> protein related to the human β-amyloid precursor protein, is essential for viability

2 Feb 2007

Abstract excerpt

Dominant mutations in the amyloid precursor protein (APP) gene are associated with rare cases of familial Alzheimer's disease; however, the normal functions of APP and related proteins remain unclear. The nematode Caenorhabditis elegans has a single APP-related gene, apl-1, that is expressed in multiple tissues. Loss of apl-1 disrupts several developmental processes, including molting and morphogenesis, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17267616
DOI: 10.1073/pnas.0603997104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APL-1, a <i>Caenorhabditis elegans</i> protein related to the human β-amyloid precursor protein, is essential for viabilityPMID 17267616Read ↗

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.Semantic proximity Read ↗

APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development.Semantic proximity Read ↗

The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans.Semantic proximity Read ↗

AIP-1 ameliorates β-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease modelSemantic proximity Read ↗

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.Semantic proximity Read ↗

A Familial Alzheimer’s Disease Associated Mutation in Presenilin-1 Mediates Amyloid-Beta Independent Cell Specific NeurodegenerationSemantic proximity Read ↗

A familial Alzheimer's disease associated mutation in presenilin-1 mediates amyloid-beta independent cell specific neurodegeneration.Semantic proximity Read ↗

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseasesSemantic proximity Read ↗

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.Semantic proximity Read ↗

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.Semantic proximity Read ↗

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling.Semantic proximity Read ↗

acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.