Article

CasPEDIA Database: A Functional Classification System for Class 2 CRISPR-Cas Enzymes

2023-08-17

Abstract excerpt

CRISPR-Cas enzymes enable RNA-guided bacterial immunity and are widely used for biotechnological applications including genome editing. In particular, the Class 2 CRISPR-associated enzymes (Cas9, Cas12 and Cas13 families), have been deployed for numerous research, clinical and agricultural applications. However, the immense genetic and biochemical diversity of these proteins in the public domain poses a barrier fo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f07a7e60-0b09-5ed2-a012-568d102ddda6
DOI: 10.32942/x2c31f

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CasPEDIA Database: A Functional Classification System for Class 2 CRISPR-Cas EnzymesDOI 10.32942/x2c31fRead

A deep learning and co-conservation framework enable discovery of non-canonical Cas proteinsSemantic proximity Read

CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYingSemantic proximity Read

Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering ToolboxSemantic proximity Read

CasPDB: an integrated and annotated database for Cas proteins from bacteria and archaeaSemantic proximity Read

Expanding the CRISPR toolbox by engineering Cas12a orthologs of metagenomic discoverySemantic proximity Read

CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactionsSemantic proximity Read

Characterization of Cas12a nucleases reveals diverse PAM profiles between closely-related orthologs.Semantic proximity Read

Metagenomic discovery of novel CRISPR-Cas13 systemsSemantic proximity Read

Structural principles of CRISPR-Cas enzymes used in nucleic acid detectionSemantic proximity Read

Anti-CRISPRdb: a comprehensive online resource for anti-CRISPR proteinsSemantic proximity Read

A Combinatorial Approach towards Adaptability of 22 Functional Cas12a Orthologs for Nucleic Acid Detection in Clinical SamplesSemantic proximity Read

Initial Characterization of 12 New Subtypes and Variants of Type V CRISPR Systems.Semantic proximity Read