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CD4 <sup>+</sup> T cells from chronic Chagas disease patients with different degrees of cardiac compromise exhibit distinct expression patterns of inhibitory receptors TIGIT, Tim-3 and Lag-3

2019-07-08

Abstract excerpt

T cells are central to adaptive immune response against T. cruzi infection. In the chronic stage of Chagas disease, circulating parasite-specific memory T cells show reduced functionality and increased expression of inhibitory receptors, possibly as a result of persistent antigenic stimulation. This exhausted phenotype has been linked to progression of cardiac pathology while, contrariwise, the presence of polyfu...

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Literature Corpus work
f07389c9-8b3b-58d5-9246-2ef8d8044a3e
DOI
10.1101/694729
Open publication

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CD4 <sup>+</sup> T cells from chronic Chagas disease patients with different degrees of cardiac compromise exhibit distinct expression patterns of inhibitory receptors TIGIT, Tim-3 and Lag-3DOI 10.1101/694729
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