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Cytotoxic CD4 <sup>+</sup> T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate <i>Trypanosoma cruzi</i> -infected hearts

2021-10-22

Abstract excerpt

Increasing attention has been directed to cytotoxic CD4 + T cells (CD4CTLs) in different pathologies, both in humans and mice. The impact of CD4CTLs in immunity and the mechanisms controlling their generation, however, remain poorly understood. Here, we show that CD4CTLs abundantly differentiate during mouse infection with the intracellular parasite Trypanosoma cruzi . CD4CTLs display parallel kinetics to Th1 ce...

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Literature Corpus work
8b8de69a-ab70-537a-adb7-897a4a1a7bb1
DOI
10.1101/2021.10.21.465260
Open publication

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Cytotoxic CD4 <sup>+</sup> T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate <i>Trypanosoma cruzi</i> -infected heartsDOI 10.1101/2021.10.21.465260
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