Article
Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors.
Gastroenterology - 1 Feb 2014
Kroy Daniela C, Ciuffreda Donatella, Cooperrider Jennifer H, Tomlinson Michelle, Hauck Garrett D, Aneja Jasneet, Berger Christoph, Wolski David, Carrington Mary, Wherry E John, Chung Raymond T, Tanabe Kenneth K, Elias Nahel, Freeman Gordon J, de Kruyff Rosemarie H, Misdraji Joseph, Kim Arthur Y, Lauer Georg M
Abstract excerpt
BACKGROUND & AIMS: There is an unclear relationship between inhibitory receptor expression on T cells and their ability to control viral infections. Studies of human immune cells have been mostly limited to T cells from blood, which is often not the site of infection. We investigated the relationship between T-cell location, expression of inhibitory receptors, maturation, and viral control using blood and liver T...
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