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Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against <i>Trypanosoma cruzi</i> Antigens in Chronic Chagasic Patients

19 Sept 2015

Abstract excerpt

In mammals, chronic diseases resulting from infectious agents have been associated with functional T cell response deficiency, a high frequency of terminally differentiated T cells, the presence of monofunctional Ag-specific T cells, and increased expression of inhibitory receptors. Similar to other chronic diseases, the progressive loss of certain functional activities during Trypanosoma cruzi infection might...

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PMID: 26385520
DOI: 10.4049/jimmunol.1500459

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