Article

KRAS-Mediated CCDC6 Degradation Drives xCT Upregulation and Ferroptosis Evasion

2026-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic KRAS mutations drive tumorigenesis by promoting pro-survival signaling and metabolic reprogramming, including the maintenance of redox balance to evade oxidative stress. A key mechanism involves the upregulation of the xCT cystine/glutamate antiporter, which sustains glutathione (GSH) synthesis and protects cells from oxidative damage and ferroptosis. While it is known that the ETS1-AT...

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Literature Corpus work: f0639665-668f-5571-b517-13a8ed4cfa9e
DOI: 10.64898/2026.05.05.721389

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