Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression

20 Jul 2023

Abstract excerpt

Ferroptosis has emerged to be a promising approach in cancer therapies; however, colorectal cancer (CRC) is relatively insensitive to ferroptosis. Exactly how the gut microenvironment impacts the ferroptotic sensitivity of CRC remains unknown. Herein, by performing metabolomics, we discovered that butyrate concentrations were significantly decreased in CRC patients. Butyrate supplementation sensitized CRC mice to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37494767
DOI: 10.1016/j.redox.2023.102822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppressionPMID 37494767Read ↗

Characterization of butyrate-metabolism in colorectal cancer to guide clinical treatmentSemantic proximity Read ↗

Bioinformatics and experimental unveiling of TIMP1 as a novel therapeutic target in colorectal cancer ferroptosisSemantic proximity Read ↗

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expressionSemantic proximity Read ↗

Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cellsSemantic proximity Read ↗

Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosisSemantic proximity Read ↗

β-hydroxybutyrate resensitizes colorectal cancer cells to oxaliplatin by suppressing H3K79 methylation in vitro and in vivoSemantic proximity Read ↗

Roseburia intestinalis sensitizes colorectal cancer to radiotherapy through the butyrate/OR51E1/RALB axisSemantic proximity Read ↗

KRAS-Mediated CCDC6 Degradation Drives xCT Upregulation and Ferroptosis EvasionSemantic proximity Read ↗

Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axisSemantic proximity Read ↗

KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion.Semantic proximity Read ↗

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)Semantic proximity Read ↗

Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.