Article

Precursor of chemically expanded hepatocytes (pre-cHep) with 1-million-fold expansion potential and liver repopulation capacity

2026-05-19

Abstract excerpt

Primary human hepatocytes (PHHs) are the gold standard for toxicology and drug metabolism studies in industry. However, their limited availability, substantial batch-to-batch variability, and high cost restrict their use. Here, we report a novel culture condition that reprograms PHHs into a proliferative state. These proliferating cells, termed precursors of chemically expanded hepatocytes (pre-cHep), expand over...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f05840b3-5e00-56b8-b365-48d7f129175a
DOI: 10.64898/2026.05.15.725446

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Precursor of chemically expanded hepatocytes (pre-cHep) with 1-million-fold expansion potential and liver repopulation capacityDOI 10.64898/2026.05.15.725446Read

Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human HepatocytesSemantic proximity Read

Robust Expansion and Functional Maturation of Human Hepatoblasts by Chemical StrategySemantic proximity Read

Three-Dimensional Liver Culture Systems to Maintain Primary Hepatic Properties for Toxicological Analysis In VitroSemantic proximity Read

Expandable, Functional Hepatocytes Derived from Primary Cells Enable Liver TherapeuticsSemantic proximity Read

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functionsSemantic proximity Read

The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture systemSemantic proximity Read

Standard Protocols for Characterising Primary and In Vitro‐Generated Human HepatocytesSemantic proximity Read

Large‐Scale Production of Expandable Hepatoblast Organoids and Polarised Hepatocyte Organoids From hESCs Under 3D Static and Dynamic Suspension ConditionsSemantic proximity Read

Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.Semantic proximity Read

Cell sources for <i>in vitro</i> human liver cell culture modelsSemantic proximity Read

Development of optimised human iPSC-derived hepatocytes with improved liver function for <i>in vitro</i> metabolic disease modelling and toxicity studiesSemantic proximity Read

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical researchSemantic proximity Read