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Large‐Scale Production of Expandable Hepatoblast Organoids and Polarised Hepatocyte Organoids From hESCs Under 3D Static and Dynamic Suspension Conditions

8 Feb 2025

Abstract excerpt

ABSTRACT To date, generating viable and functional hepatocytes in large scale remains challenge. By employing 3D suspension condition with the support of low concentration Matrigel, a novel culture system was developed to generate expandable hepatoblast organoids (HB‐orgs) and mature polarised hepatocyte organoids (P‐hep‐orgs) from human embryonic stem cells (hESCs) in both dishes and bioreactors. scRNA‐seq and...

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PMID: 39921573
DOI: 10.1111/cpr.70001

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