Article
Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene.
The Journal of biological chemistry - 8 Jun 2012
Leong Dillon W, Komen Jasper C, Hewitt Chelsee A, Arnaud Estelle, McKenzie Matthew, Phipson Belinda, Bahlo Melanie, Laskowski Adrienne, Kinkel Sarah A, Davey Gayle M, Heath William R, Voss Anne K, Zahedi René P, Pitt James J, Chrast Roman, Sickmann Albert, Ryan Michael T, Smyth Gordon K, Thorburn David R, Scott Hamish S
Abstract excerpt
Eukaryotic cells generate energy in the form of ATP, through a network of mitochondrial complexes and electron carriers known as the oxidative phosphorylation system. In mammals, mitochondrial complex I (CI) is the largest component of this system, comprising 45 different subunits encoded by mitochondrial and nuclear DNA. Humans diagnosed with mutations in the gene NDUFS4, encoding a nuclear DNA-encoded subunit...
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