Article

Granulin <sup>+</sup> macrophages promote lineage plasticity in prostate cancer through paracrine signaling loops

2025-07-14

Abstract excerpt

The role of tumor-infiltrating immune cells in driving phenotype switching remains unclear, despite the well-established association between lineage transition and drug resistance in prostate cancer. This study employed an integrated analysis of single-cell multiomics to investigate the dynamics of immune infiltration, transcriptional programs, and cell-cell communication in prostate cancer. Our results demonstrat...

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Literature Corpus work: f03d5024-aebb-561d-8c3d-bab8633ed307
DOI: 10.1101/2025.07.09.663835

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