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A Mendelian randomisation study of smoking causality in IPF compared with COPD

2020-12-07

Abstract excerpt

In a normal year, the fatal lung disease Idiopathic Pulmonary Fibrosis (IPF) accounts for ∼1% of UK deaths. Smoking is a recognised risk factor for IPF but the question of causality remains unanswered. Here, we used data from the UK Biobank (UKBB) and the well-established genetic technique of Mendelian randomisation (MR) methods to investigate whether smoking is causal for IPF compared with COPD, where causality i...

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Literature Corpus work
f0308800-7d35-5277-a53f-c72d79b36c1c
DOI
10.1101/2020.12.04.20243790
Open publication

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