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The causal relationship between gastro-esophageal reflux disease and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study

2022-09-01

Abstract excerpt

<h4>Background</h4> Gastro-esophageal reflux disease (GERD) is associated with idiopathic pulmonary fibrosis (IPF) in observational studies. It is not known if this association arises because GERD causes IPF, or IPF causes GERD, or because of confounding by factors, such as smoking, associated with both GERD and IPF. We used bidirectional Mendelian randomisation (MR), where genetic variants are used as instrumenta...

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Literature Corpus work
e37fb05f-b806-543a-9b85-4668559ef5ef
DOI
10.1101/2022.08.31.22279411
Open publication

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The causal relationship between gastro-esophageal reflux disease and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization studyDOI 10.1101/2022.08.31.22279411
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