Article
Mendelian randomisation highlights hypothyroidism as a causal determinant of idiopathic pulmonary fibrosis.
EBioMedicine - 1 Nov 2021
Zhang Yanan, Zhao Meng, Guo Ping, Wang Yanjun, Liu Lu, Zhao Jinghua, Gao Ling, Yuan Zhongshang, Xue Fuzhong, Zhao Jiajun
Abstract excerpt
BACKGROUND: Although the association between hypothyroidism and idiopathic pulmonary fibrosis (IPF) is found in observational studies, it remains uncertain whether hypothyroidism causally influences IPF. METHODS: Two-sample Mendelian randomisation (MR) was conducted with hypothyroidism genome-wide association study (GWAS) data in the UK Biobank from 289,307 individuals (18,740 cases and 270,567 controls) and the...
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