Article
Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered cranial neurogenesis.
Disease models & mechanisms - 1 Jun 2024
Hampl Marek, Jandová Nela, Lusková Denisa, Nováková Monika, Szotkowská Tereza, Čada Štěpán, Procházka Jan, Kohoutek Jiri, Buchtová Marcela
Abstract excerpt
CDK13-related disorder, also known as congenital heart defects, dysmorphic facial features and intellectual developmental disorder (CHDFIDD) is associated with mutations in the CDK13 gene encoding transcription-regulating cyclin-dependent kinase 13 (CDK13). Here, we focused on the development of craniofacial structures and analyzed early embryonic stages in CHDFIDD mouse models, with one model comprising a...
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