The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal development

Abstract excerpt

BACKGROUND: Heterozygous mutations in the chromatin remodeling gene CHD7 cause CHARGE syndrome, a developmental disorder with variable craniofacial dysmorphisms and respiratory difficulties. The molecular etiologies of these malformations are not well understood. Homozygous Chd7 null mice die by E11, whereas Chd7(Gt/+) heterozygous null mice are a viable and excellent model of CHARGE. We explored skeletal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cleft Lip and Palate Research
• Share to Congenital Ear and Nasal Anomalies
• Share to Ear Surgery and Otitis Media