Article

A patient-derived blood-brain barrier model for screening copper bis(thiosemicarbazone) complexes as potential therapeutics in Alzheimer’s disease

2023-08-21

Abstract excerpt

Alzheimer’s disease (AD) is the most prevalent cause of dementia characterised by progressive cognitive decline. Addressing neuroinflammation represents a promising therapeutic avenue to treat AD, however, the development of effective anti-neuroinflammatory compounds is often hindered by their limited blood-brain barrier (BBB) permeability. Consequently, there is an urgent need for accurate, preclinical AD patient...

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Literature Corpus work: f0067c5a-d569-5f4b-bd7e-3e89243c2246
DOI: 10.1101/2023.08.20.554047

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