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Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer's Disease Models.

ACS chemical neuroscience - 16 Nov 2016

Zhou Wei, Zhong Guifa, Fu Sihai, Xie Hui, Chi Tianyan, Li Luyi, Rao Xiurong, Zeng Shaogao, Xu Dengfeng, Wang Hao, Sheng Guoqing, Ji Xing, Liu Xiaorong, Ji Xuefei, Wu Donghai, Zou Libo, Tortorella Micky, Zhang Kejian, Hu Wenhui

Abstract excerpt

Currently, anti-AD drug discovery using target-based approaches is extremely challenging due to unclear etiology of AD and absence of validated therapeutic protein targets. Neuronal death, regardless of causes, plays a key role in AD progression, and it is directly linked to neuroinflammation. Meanwhile, phenotypic screening is making a resurgence in drug discovery process as an alternative to target-focused...

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PMID: 27504670
DOI: 10.1021/acschemneuro.6b00125

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APP

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